ea0037gp.30.07 | Endocrine tumours and neoplasia – General | ECE2015
Hofland Johannes
, Taylor Angela E
, Turgeman Orli
, O'Neil Donna M
, Foster Paul A
, Arlt Wiebke
Introduction: Prostate cancer (PC) is dependent on androgen receptor (AR) activation by its canonical ligands testosterone and 5α-dihydrotestosterone (DHT). Intratumoural androgens persisting after castration give rise to castration-resistant PC (CRPC). These intraprostatic androgen levels are hypothesized to result from either adrenal androgen conversion or intratumoural de novo DHT synthesis through the classic or alternative pathways. Quantifying the steroid f...